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Experimental comparison between the effect of standardized trazodone-amitriptyline and placebo treatment in vitalized depressive patients

✍ Scribed by E. Klieser; E. Lehmann

Publisher: Springer
Year: 1988
Tongue: English
Weight: 254 KB
Volume: 95
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00172621

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✦ Synopsis

We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were given at random. All patients received the same type of cognitive behaviour therapy. The test battery consists of CGI, BPRS, HAMD, HAMA and AMDP; adverse drug reactions are documented as "free reports" (= freier Nebenwirkungsbericht). The interim results (until March 1987) will be presented. Our investigation indicates that it is probable that the trazodone treatment we used is equivalent to corresponding amitriptyline treatment.

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