✦ LIBER ✦

Experimental Combination Chemotherapy with Thymidylate Synthetase and Ribonucleotide Reductase Inhibitors

✍ Scribed by Shu Kobayashi; Takao Hoshino; Daniel V. Santi

Book ID: 114421217
Publisher: Springer US
Year: 1984
Tongue: English
Weight: 537 KB
Volume: 01
Category: Article
ISSN: 0724-8741
DOI: 10.1023/a:1016304809876

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Implications and problems in analysing c

Implications and problems in analysing cytotoxic activity of hydroxyurea in combination with a potential inhibitor of ribonucleotide reductase

✍ Giuseppe Nocentini; Anna Barzi; Palmarisa Franchetti 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 645 KB

Enhancement of hemoglobin and F-cell pro

Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin

✍ Iyamu, W.E.; Adunyah, S.E.; Fasold, H.; Horiuchi, K.; Elford, H.L.; Asakura, T.; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 650 KB

Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase

Potential for combined therapy with 348u

Potential for combined therapy with 348u87, a ribonucleotide reductase inhibitor, and acyclovir as treatment for acyclovir-resistant herpes simplex virus infection

✍ Dr. S. Safrin; T. Schacker; J. Delehanty; E. Hill; L. Corey 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

inhibitors of the ribonucleotide reductase of herpes simplex viruses (HSV) potentiate the activity of acyclovir in vitro and in animal studies. In addition, the combination of the ribonucleotide reductase inhibitor 348U87 and acyclovir has synergistic therapeutic effects against infections in mice d

In vivo examination of hydroxyurea and t

In vivo examination of hydroxyurea and the novel ribonucleotide reductase inhibitors trimidox and didox in combination with the reverse transcriptase inhibitor abacavir: suppression of retrovirus-induced immunodeficiency disease

✍ L.Ryan Sumpter; Mohammed S. Inayat; Erin E. Yost; William Duvall; Espen Hagan; C 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 191 KB

A Phase I study of the novel ribonucleot

A Phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloproliferative disorders

✍ Judith E. Karp; Francis J. Giles; Ivana Gojo; Lawrence Morris; Jacqueline Greer; 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 117 KB

Ribonucleotide reductase inhibitors, did

Ribonucleotide reductase inhibitors, didox and trimidox, demonstrate antiretroviral activity alone or in combination with DDI in a murine acquired immunodeficiency (MAIDS) model: H. Elford1, B. Van't Riet1, C. Mayhew2, O. Oakley2, N. Hughes2, J. Piper2, V. Gallicchio2. 1Molecules for Health, Inc., Richmond, VA; 2University of Kentucky, Lexington, KY

📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 104 KB