Experimental candidiasis associated with liver injury

✍ Scribed by Fumihiko Abe; Tadashi Katoh; Hayashi Inaba; Masao Hotchi

• Book ID: 104773454
• Publisher: Springer Netherlands
• Year: 1988
• Tongue: English
• Weight: 295 KB
• Volume: 104
• Category: Article
• ISSN: 0301-486X
• DOI: 10.1007/bf00437917

✦ Synopsis

In an attempt to perform a further investigation on the proposal that an increasing susceptibility to Candida infection in liver injury may be related to unsaturated transferin level (UIBC) and/or to a total amount of transferrin represented by TIBC, we conducted experimental candidiasis using mice with galactosamine-induced liver injury and investigated the effect of preadministration of transferrin prior to inoculation of Candida albicans. Final mortality was 10~ in the mice without liver injury and without transferrin (Group !) and ones with liver injury and with transferrin (Group 3). By contrast a 50o7o mortality was given in ones only with liver injury (Group 2). The TIBCs in Groups 1 and 3 were significantly higher than that in Group 2. The UIBCs in Groups 2 and 3, although there was no significant difference between them, were significantly lower than that in Group 1. This study confirmed that transferrin (TIBC) may have a direct deterring effect on systemic Candida infection and the decreased TIBC in the liver injury enhances the growth of C. albicans.