Experimental approaches to interfere with the polysialylation of the neural cell adhesion molecule in vitro and in vivo
✍ Scribed by Kaya Bork; Daniel Gagiannis; André Orthmann; Wenke Weidemann; Maria Kontou; Werner Reutter; Rüdiger Horstkorte
- Book ID
- 111180284
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 442 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0022-3042
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## Modulation of neural cell adhesion molecule polysialylation (NCAM PSA ) state has been proposed to underlie morphofunctional change associated with consolidation of memory in the rodent, and its agedependent decline to be related to impaired cognitive function. To establish whether this may be a
## Abstract During memory consolidation neuroplastic events in the mediotemporal corticohippocampal pathway are accompanied by transient increases in the frequency of neurons expressing polysialylated neural cell adhesion molecule (NCAM PSA), a posttranslational modification associated with morphof
## Abstract Cell adhesion molecule function is involved in hippocampal synaptic plasticity and is associated with memory consolidation. At the infragranular zone of the dentate gyrus, neurons expressing the polysialylated form of the neural cell adhesion molecule (NCAM PSA) transiently increase the