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Experimental and theoretical structural study of 2-pyridyl- and 4-hydroxyphenyl-1,4-dihydropyridine derivatives

✍ Scribed by Héctor Novoa De Armas; Norbert Blaton; Oswald M. Peeters; Camiel De Ranter; Margarita Suárez; Emilio Rolando; Yamila Verdecia; Estael Ochoa; Nazario Martín; Margarita Quinteiro; Carlos Seoane; José L. Soto

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
516 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of substituted 1,4‐dihydropyridines (1,4‐DHPs) has been synthesised following the well‐known Hantzsch's procedure for symmetrical 1,4‐DHP. The structures of these compounds have been thoroughly studied by X‐ray crystallographic analysis and semiempirical (AMI) calculations. A good agreement is found between the theoretical and experimental results. In all cases, the most stable conformation fulfils all the requirements needed for exhibiting an antagonist calcium effect.

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