A kinetic study of the reduction of nitric oxide (NO) by isobutane in simulated conditions of the reburning zone was carried out in a fused silica jet-stirred reactor operating at 1 atm, at temperatures ranging from 1100 to 1450 K. In this new series of experiments, the initial mole fraction of NO was 1000 ppm, that of isobutane was 2200 ppm, and the equivalence ratio was varied from 0.75 to 2. It was demonstrated that for a given temperature, the reduction of NO is favored when the temperature is increased and a maximum NO reduction occurs slightly above stoichiometric conditions. The present results generally follow those reported in previous studies of the reduction of NO by C 1 to C 3 hydrocarbons or natural gas as reburn fuel. A detailed chemical kinetic modeling of the present experiments was performed using an updated and improved kinetic scheme (979 reversible reactions and 130 species). An overall reasonable agreement between the present data and the modeling was obtained. Furthermore, the proposed kinetic mechanism can be successfully used to model the reduction of NO by ethylene, ethane, acetylene, a natural gas blend (methane-ethane 10:1), propene, and HCN. According to this study, the main route to NO reduction by isobutane involves ketenyl radical. The model indicates that the reduction of NO proceeds through the reaction path: iC 4 H 10 : C 3 H 6 : C 2 H 4 : C 2 H 3 : C 2 H 2 : HCCO; HCCO ฯฉ NO : HCNO ฯฉ CO and HCN ฯฉ CO 2 ;