Experience with vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy in adults with refractory acute lymphocytic leukemia
β Scribed by Hagop M. Kantarjian; Ronald S. Walters; Michael J. Keating; Bart Barlogie; Kenneth B. McCredie; Emil J. Freireich
- Book ID
- 102670450
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 585 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0008-543X
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Four of 55 (7%) adult acute lymphocytic leukemia patients, age 27-58 years, who were treated with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD) developed avascular necrosis (AVN) of one or both femoral heads 16-39 months after beginning treatment. All patients were treated with
## Abstract ## BACKGROUND Hyperglycemia, which is not uncommon during the treatment of acute lymphocytic leukemia (ALL), has been shown to be an independent predictor of adverse outcomes among hospitalized patients with undiagnosed diabetes; it also may have the potential to affect leukemic cell p