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Experience with neonatal screening for cystic fibrosis in New Zealand using measurement of immunoreactive trypsinogen

✍ Scribed by A. W. WESLEY; P. A. SMITH; R. B. ELLIOTT


Book ID
118706253
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
473 KB
Volume
25
Category
Article
ISSN
1034-4810

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We have evaluated a two-tier neonatal cystic fibrosis (CF) screening of immunoreactive trypsinogen (IRT) followed by CFTR gene mutation analysis using a systematic scanning of exons 7, 10, and 11, and, if necessary, by direct DNA sequencing. Over an 18-month period we screened 32,300 neonates born i