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Experience with a Placebo-Controlled Randomized Clinical Trial of a Disease-Modifying Drug for Osteoarthritis: The Doxycycline Trial

✍ Scribed by Brandt, Kenneth D.; Mazzuca, Steven A.

Book ID
122760625
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
238 KB
Volume
32
Category
Article
ISSN
0889-857X

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Effects of doxycycline on progression of
Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial
✍ Kenneth D. Brandt; Steven A. Mazzuca; Barry P. Katz; Kathleen A. Lane; Kenneth A πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 220 KB πŸ‘ 2 views

## Abstract ## Objective To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment. ## Methods In this placebo‐controlled trial, obese women (n = 431)