Experience in rat pancreas transplantation at meikai university

✍ Scribed by Dr. Masumi Nozawa; Ichiro Otsu

• Book ID: 102947913
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 770 KB
• Volume: 11
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/micr.1920110212

✦ Synopsis

Abstract

A review of rat pancreatic transplantation conducted at Meikai University is presented. It was found that pancreas transplantation normalized the endocrine based metabolic disturbances of diabetes. Arginine‐induced serum insulin, glucagon, and somatostatin responses in the grafted pancreas were similar to those in normal pancreas. Urine amylase was found to be a more sensitive marker in graft rejection as compared with blood glucose using a urinary drainage model. The value of pancreas transplantation in diabetic nephropathy was dependent upon the timing of the transplantation; performed early in the course of diabetes (less than 4 months, post‐diabetes), it was able to reverse the nephropathy.