Expeditious synthesis of cis-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline/[2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition
β Scribed by Zhenfa Zhang; Linda P. Dwoskin; Peter A. Crooks
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 284 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In both cases, the isomer of type 8 shows the larger R, value (TLC,$30,)
The 2,3,4,4a,5, isoquinoline-7(7aH)-one ring system is prepared from a 4-arylpyridine precursor by sequential intramolecular enolate addition to a pyridinium ion, Dieckmann cyclization, and catalytic hydrogenation.
-5,6,7,8,9,10-hexahydro-1,3-cycloheptapyrimidino[2,3-b] thiazole-2-spiro-3 0 0 0 -pyrrolidine-2 0 0 0 -spiro-3 0 0 00 0 0 -1H-indole-2 0 0 00 0 0 ,3(2H,3 0 0 00 0 0 H)-dione
-5,6,7,8,9,10-hexahydro-1,3-cyclooctapyrimidino[2,3-b] thiazole-2-spiro-3 0 0 0 -pyrrolidine-2 0 0 0 -spiro-3 0 0 00 0 0 -1H-indole-2 0 0 00 0 0 ,3(2H,3 0 0 00 0 0 H)dione