Expansion of the CD4−, CD8− γδ T cell subset in the spleens of mice during non-lethal blood-stage malaria

✍ Scribed by Henri C. van der Heyde; M. Merle Elloso; Derry C. Roopenian; Dean D. Manning; William P. Weidanz

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 512 KB
• Volume: 23
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830230817

✦ Synopsis

Splenic y6 T cells (CD4-, CD8-) increased more that 10-fold upon resolution of either Plasmodium chabaudi adami or P c. chabaudi infections in C57BL/6 mice compared to controls. Similarly, a 10-to 20-fold expansion of the y6 T cell population was observed in microglo globulin deficient (P2-mn' O) mice that had resolved P c. adami, l? c. chabaudi or I? yoelii yoelii infections. In contrast, increases in the number of splenic aP T cells in these infected mice were only two to three-fold indicating a differential expansion of the y6 T cell subset during malaria. Because nucleated cells of P2-moIn mice lack surface expression of major histocompatibility complex class I and class Ib glycoproteins, our findings suggest that antigen presentation by these glycoproteins is not necessary for the increasing number of y6 T cells. Our observation that after resolution of II c. adami malaria, C57BL/6 mice depleted of CD8+ cells by monoclonal antibody treatment had lower numbers of y6 T cells than untreated controls suggests that the demonstrated lack of CD8+ cells in P2-molo mice does not contribute to the expansion of the y6 T cell population during non-lethal malaria.