Expansion of CD4+ and CD8+ tumor-infiltrating lymphocytes (TILs) in situ following adoptive immunotherapy in a murine tumor model: cytokine gene expression

Differential in situ expansion and gene

Differential in situ expansion and gene expression of CD4+ and CD8+ tumor-infiltrating lymphocytes following adoptive immunotherapy in a murine tumor model system

✍ Robert Evans; Theodore M. Duffy; Sonya J. Kamdar 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 584 KB

## Abstract In previous reports, we demonstrated that adoptively transferred T cells homed to the tumor site (among other sites) and that amplification of immune responses occurred __in situ__ leading to the generation of cytotoxic CD8^+^ tumor‐infiltrating lymphocytes (TIL) and macrophages. The pr