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Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-pyrazolidinediones

✍ Scribed by Xu-Yang Zhao; William A. Metz; Frank Sieber; Kim D. Janda

Book ID: 104260141
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 217 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01921-2

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✦ Synopsis

Isopropanol was found to be an excellent solvent for the precipitation of PEG-bound molecules. Polar reagents and by-products, even those generated as a result of using benzotriazol-l-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) or benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (PyBOP) coupling reagents, are soluble in iPrOH allowing clean precipitation of the polymer-bound species. Several examples axe given to support the general utility of this precipitation method which allowed for the synthesis of a 3,5-pyrazolidinedione on soluble PEG polymer support.

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