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ExonSuite: Algorithmically optimizing alternative gene splicing for the PUF proteins

✍ Scribed by Ustek, Dilan; Kohrman, Abraham; Krstic, Bogdan; Fernandez, Karissa

Book ID
122904297
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
170 KB
Volume
43
Category
Article
ISSN
0010-4825

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One of the features expected of the gene trap approach is the functional mutation of a gene, allowing its loss-of-function phenotype analysis. We have mutated the murine microtubule-associated protein 4 (MAP-4) locus by inserting a splice-acceptor gene trap construct. Because the MAP-4 gene has been