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Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

✍ Scribed by Agrawal, Nishant (author);Frederick, Mitchell J. (author);Pickering, Curtis R. (author);Bettegowda, Chetan (author);Chang, Kyle (author);Li, Ryan J. (author);Fakhry, Carole (author);Xie, Tong Xin (author);Zhang, Jiexin (author);Wang, Jing (author);Zhang, Nianxiang (author);El-Naggar, Adel K. (author);Jasser, Samar A. (author);Weinstein, John N. (author);Treviño, Lisa (author);Drummond, Jennifer A. (author);Muzny, Donna M. (author);Wu, Yuanqing (author);Wood, Laura D. (author);Hruban, Ralph H. (author);Westra, William H. (author);Koch, Wayne M. (author);Califano, Joseph A. (author);Gibbs, Richard A. (author);Sidransky, David (author);Vogelstein, Bert (author);Velculescu, Victor E. (author);Papadopoulos, Nickolas (author);Wheeler, David A. (author);Kinzler, Kenneth W. (author);Myers, Jeffrey N. (author)

Book ID
111900576
Publisher
American Association for the Advancement of Science
Year
2011
Tongue
English
Weight
149 KB
Volume
333
Category
Article
ISSN
0036-8075

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Mutational analysis of the PTEN gene in
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## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci