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Existence of steady-state probability distributions in multilocus models for genotype evolution

✍ Scribed by Gerald Rosen

Book ID
104272593
Publisher
Springer
Year
1986
Tongue
English
Weight
531 KB
Volume
48
Category
Article
ISSN
1522-9602

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✦ Synopsis

It is shown that a representative

Fisher-Wright model with n( 23) diallelic loci admits a necessary condition for existence of a time-independent steady-state probability distribution. This necessary condition states that a global integral depending on the phenotype fitness functions of natural selection must be larger than a certain quantity depending on the parameters associated with genetic drift.

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A valid equation for the well-stirred pe
A valid equation for the well-stirred perfusion limited physiologically based pharmacokinetic model that consistently accounts for the blood–tissue drug distribution in the organ and the corresponding valid equation for the steady state volume of distribution
✍ Leonid M. Berezhkovskiy πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 165 KB πŸ‘ 1 views

A consistent account of the assumptions of the well-stirred perfusion limited model leads to the equation for the organ tissue that does not coincide with that often presented in books and papers. The difference in pharmacokinetic profiles calculated by the valid and the commonly used equations coul