Existence of a small population of IL-2Rβhi TCRint cells in SCG and MRL-lpr/lpr mice which produce normal Fas mRNA and Fas molecules from the lpr gene
✍ Scribed by Satoshi Yamagiwa; Yuh Kuwano; Katsuhiko Hasegawa; Kazunari Sato; Kazuo Ohtsuka; Tsuneo Iiai; Katsuhiro Tomiyama; Hisami Watanabe; Satoshi Sugahara; Shuhji Seki; Hitoshi Asakura; Toru Abo
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 756 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Mice carrying the lpr gene, SCG and MRL-lprllpr mice, were used to characterize the phenotype and lpr gene of abnormally proliferating T cells in these mice. A major population which expanded in these mice were T cells expressing intermediate (int) levels of Tcell receptor (TCR) (and CD3) and the phenotype of interleukin-2 receptor (IL-2R)P'" a-(possibly abnormal TCR'"' cells). The levels of TCRh' cells of thymic origin (generated through the mainstream of Tcell differentiation in the thymus) profoundly decreased after the onset of disease. However, a small population of normal TCR'"' cells (i.e. IL-2RPh' a-) were also found to exist in all tested organs. For example, the majority of abnormal IL-2RP'" TCR'"' cells were CD4-8-CD2-, while normal IL-2RPh' TCR"' cells were a mixture of single-positive cells (mainly CD8+), CD4-8-cells and CD2' cells. Moreover, normal TCR'"' cells preferentially produced normal Fas mRNA and Fas molecules from the lpr gene. This phenomenon explains the leaky appearance of normal Fas mRNA and Fas molecules in mice carrying the lpr gene. It is suggested that a small population of IL-2RPh'TCR"' cells are resistant to the lpr genetic abnormality.
~~