Exhaled nitric oxide in children measured by tidal breathing method: Differences between asthmatics and nonasthmatic controls
✍ Scribed by M.J. Visser; M.-C.Y. de Wit; W.M.C. van Aalderen; D.S. Postma; P.L.P. Brand
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 35 KB
- Volume
- 29
- Category
- Article
- ISSN
- 8755-6863
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✦ Synopsis
The single-breath maneuver used to measure nitric oxide (NO) in adults cannot be performed by young children. We, therefore, developed a method of measuring NO in mixed exhaled gas collected during tidal breathing. NO was measured in mixed exhaled gas during 5 min of tidal breathing in 113 children 4-14 years of age: 22 nonasthmatics, 21 asthmatic children not taking inhaled corticosteroids, and 70 asthmatic children using inhaled corticosteroids. Exhaled NO levels (median, range) were significantly lower in nonasthmatic controls (median, range: 7, 2-10 ppb) than in asthmatic children on inhaled corticosteroids (8, 3-25 ppb; 95% CI for difference in medians with those of controls, 0-4 ppb), and in those not on inhaled corticosteroids (13, 6-37, ppb; 95% CI for difference in medians, 5-17 ppb). Asthmatic children not using inhaled corticosteroids had significantly higher exhaled NO levels than asthmatic children using inhaled corticosteroids (95% CI for difference in medians, 3-10 ppb). The tidal breathing method is a useful and practical way of measuring exhaled NO levels in children regardless of their age.