Exercises in Organic Synthesis Based on Synthetic Drugs

✍ Scribed by Nora de Souza M.V.

• Publisher: Bentham Books
• Year: 2020
• Tongue: English
• Leaves: 250
• Category: Library

✦ Synopsis

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development.Key Features:- Presents information about different techniques and strategies for the synthesis of organic compounds- Covers a broad range of biologically active compounds- Easy to read topical presentation- Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry- Wide range of bibliographic references for further reading and exercises presented,Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.

✦ Table of Contents

Cover
Exercises in Organic Synthesis Based on Synthetic Drugs
Copyright
End User License Agreement
Contents
Preface
Consent for Publication
Conflict of Interest
Acknowledgements
1. How to Build a Drug: Exercises Based on the Concept of Retrosynthetic Analysis
Introduction
Protective Groups
Exercises 1 to 4 - Retrosynthetic Analysis
Exercise 1 - Two Synthons = Drug
Example
Answer
Exercises
Answers
Exercise 2 – Epoxides
Example
Answer
Exercises
Answers
Exercise 3 – Piperazine and Related Substances
Examples
Answers
Exercises
Answers
Exercise 4 – Aldehydes
Examples
Answers
Exercises
Answers
Conclusion of the Exercises 1 to 4 (Retrosynthetic Analysis)
References
2. Organizing Synthetic Routes and Identifying Reagents
Exercises 5 to 8
Introduction
Exercise 5 - Organizing Synthetic Routes
Example
Answer
Exercises
Ruthenium and its Complexes as Oxidants
Mechanism of Wittig-Horner Reaction
Exercise 6 - Identifying Reagents
Example
Answer
Exercises
Answers
Conclusion of the Exercises 5 and 6 (Organizing Synthetic Routes and Identifying Reagents)
3. Identifying Drug Structure and Completing the Gaps
Exercise 7 - Identifying Drug Structure
Examples
Answers
Exercises
Answers
Exercise 8 - Completing the Gaps
Example
Answer
Exercises
Answers
Conclusion of Exercises 7 and 8 (Identifying Drug Structure and Completing the Gaps)
References
4. Heteroaromatic Substances
Five-Membered Rings
Six-Membered Rings
Fused Systems
Example
Answer
Mechanism of Reaction
Exercises
Answers
Conclusion
5. Hydrazine and its Derivatives
Introduction
Example
Answer
Exercises
Answers
Conclusion
6. Nitriles
Introduction
Example
Answer
Exercises
Answers
Conclusion
7. Combinatorial Chemistry
Introduction
Example
Answer
Mechanism of Reaction
Exercises
Answers
Conclusion
References
8. Multicomponent Reaction (MCR)
Introduction
Example
Answer
Important Note
Exercises
Answers
Conclusion
9. Click Chemistry
Introduction
Example
Answer
Exercises
Answers
Conclusion
References
10. Fluorine in Drug Discovery
Introduction
Fluorination Reagents
Nucleophilic Fluorination for the Introduction of Fluorine Atom NaF, KF, HF, and Bu4NF
Diethylaminosulfur Trifluoride (DAST)
Nucleophilic Fluorination for the Introduction of the Trifluoromethyl Group
Eletrophilic Fluorination for the Introduction of Fluorine Atoms
Electrophilic Fluorination for the Introduction of the Trifluoromethyl Group
Radical Fluorination
Classical Examples of the Importance of Fluorine in Drug Development
Fluoroquinolone
Sitagliptin
Odanacatib
Celecoxib
Example
Answer
EXERCISES
Answers
Conclusion
References
List of Journals Used and Their Respective Abbreviations
List of Abbreviations
Subject Index
Cover back