Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing
✍ Scribed by Q. Ding; Z. Ying; F. Gómez-Pinilla
- Book ID
- 116789476
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 973 KB
- Volume
- 192
- Category
- Article
- ISSN
- 0306-4522
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Brain-derived neurotrophic factor (BDNF) enhances synaptic plasticity and neuron function. We have reported that voluntary exercise increases BDNF mRNA levels in the hippocampus; however, mechanisms underlying this regulation have not been defined. We hypothesized that medial septal cholinergic and/
## Abstract The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain‐derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed