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Exendin 4 Up-Regulates Expression of PDX 1 and Hastens Differentiation and Maturation of Human Fetal Pancreatic Cells

✍ Scribed by Movassat, Jamileh; Beattie, Gillian M.; Lopez, Ana D.; Hayek, Alberto

Book ID
126897937
Publisher
Endocrine Society
Year
2002
Tongue
English
Weight
734 KB
Volume
87
Category
Article
ISSN
0021-972X

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Exendin-4 differentiation of a human pan
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## Abstract Exendin‐4 (EX‐4), a long acting agonist of GLP‐1, induces an endocrine phenotype in Capan‐1 cells. Under culture conditions which include serum, ∼10% of the cells contain insulin and glucagon. When exposed to EX‐4 (0.1 nM, up to 5 days), the number of cells containing insulin and glucag