Excretion of Xanthurenic Acid in the Urine of Women taking Progestogen-Oestrogen Preparations
β Scribed by ROSE, DAVID P.
- Book ID
- 109649958
- Publisher
- Nature Publishing Group
- Year
- 1966
- Tongue
- English
- Weight
- 258 KB
- Volume
- 210
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/210196a0
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π SIMILAR VOLUMES
Xanthurenic acid is a metabolite of L-tryptophannicotinic acid ribonucleotide biosynthesis. The excretion of xanthurenic acid from urine 24 h after ingestion of 5 g L-tryptophan is increased in depressive patients, and 17-hydroxycorticosteroids are considered of primary importance to this disorder.
Xanthurenic acid (XA) is a secondary product of the biosynthesis of nicotinamide from L-tryptophan. Disturbances in this pathway have been observed in depression. An enhanced glucocorticoid secretion is considered to induce this pathway. This could result in reduced levels of L-tryptophan (L-TRP) in