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Excretion of methoxyphenamine and its metabolites in rat urine

✍ Scribed by Tetsukichi Niwaguchi; Takado Inoue

Publisher: Elsevier Science
Year: 1978
Tongue: English
Weight: 571 KB
Volume: 161
Category: Article
ISSN: 1873-3778
DOI: 10.1016/s0021-9673(01)85230-4

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✦ Synopsis

Metabolites of methoxyphenamine in urine obtained after oral administration of the drug to rats have been isolated by Sephadex LH-20 column chromatography and identified as the O-, N,O- and N-demethylated derivatives of methoxyphenamine by thin-layer chromatography, spectrometry, and comparisons with synthesized compounds. The unchanged drug and the metabolites excreted in urine have been extracted and determined by gas chromatography after treatment with trifluoroacetic anhydride.

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