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Excluded volume effects on the kinetic assembling of a structural motif for RNA catalysis

✍ Scribed by Ariel Fernández


Book ID
103029565
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
545 KB
Volume
183
Category
Article
ISSN
0009-2614

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✦ Synopsis


We establish the role of excluded volume effects on the loss of conformational entropy due to pseudoknot formation in RNA.

This pseudoknot appears to be the structural motif responsible for shaping the splicing site of certain noncoding RNA transcriptional products. Focusing on the illustrative example of the YC4 intron, we show that the emergence of this motif is kinetically driven and prevails over competing catalytically inert secondary structure due to excluded volume effects which favor the correlation of interacting intramolecular loops ' Camille and Henry Dreyfus Teacher-Scholar.


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