Excitotoxicity induced neuronal cell loss is prevented by the HSV-2 vector ΔRR through activation of survival pathways and modulation of glial cells

Growth-compromised HSV-2 vector ΔRR prot

Growth-compromised HSV-2 vector ΔRR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades

✍ Jennifer M. Laing; Erin K. Golembewski; Samantha Q. Wales; Juan Liu; M. Samir Ja 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

## Abstract We have previously shown that intrastriatal injection of ΔRR, the growth‐compromised herpes simplex virus type 2 (HSV‐2) vector for the antiapoptotic protein ICP10PK, prevents apoptosis caused by the excitotoxin N‐methyl‐D‐aspartate (NMDA) in a mouse model of glutamatergic neuronal cell