Glutamate, the principal retinal neurotransmitter, can also act as a toxin when present in excessive concentrations as may occur in pathologies such as retinal ischemia or more generally in cerebral neuronal degenerative disease. As glial cells play pivotal roles in transfer of blood-borne molecules
Excitotoxicity in glial cells
✍ Scribed by Carlos Matute; Elena Alberdi; Gaskon Ibarretxe; Marı́a Victoria Sánchez-Gómez
- Book ID
- 114014859
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 198 KB
- Volume
- 447
- Category
- Article
- ISSN
- 0014-2999
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Glutamate is the most abundant excitatory amino acid in the central nervous system. It has also been described as a potent toxin when present in high concentrations because excessive stimulation of its receptors leads to neuronal death. Glial influence on neuronal survival has already been shown in