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Excitotoxicity in cultured neurons: role of second messenger systems and intracellular CA++ homeostasis

Book ID
123478448
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
65 KB
Volume
16
Category
Article
ISSN
0197-0186

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## Abstract The pathologic activation of NMDA receptors by glutamate is a major contributor to neuronal cell death after stroke. Receptor activation causes a massive influx of calcium into the neuron that is accumulated by the mitochondria. The favored hypothesis is that the calcium loaded mitochon