Exciplex formation in 2-propanol solutions of imidazo[4,5-f]quinolines
β Scribed by A.Ram Reddy; A.Pandu Ranga Reddy
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 451 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0047-2670
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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
Intramolecular exclplex formatIon III l\_P-naphthyl-2-N-prpendmoethane m n-butylacetate IS a clear-cut example of groundstate conformational control of a photophysuxd process The conformahonal bamer separatmg the two assembles of molecules is related to the N-mverslon and C-N rotation '"" 500 300 40
## Abstract 2βAminoβ3βmethylimidazo[4,5β__f__]quinoline (IQ) and 2βaminoβ3,8βdimethylimidazo[4,5β__f__]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active