Activation of glia has been observed in various neurodegenerative diseases. Excessive production of nitric oxide (NO), as a consequence of increased inducible nitric oxide synthase (iNOS) in glia, contributes to the neurodegeneration. The enhancement of intracellular stresses such as oxidative stres
β¦ LIBER β¦
Excessive production of nitric oxide induces the neuronal cell death in lipopolysaccharide-treated rat hippocampal slice culture
β Scribed by Pyeongjae Lee; Dongwook Son; Jongseok Lee; Yong Sik Kim; Hocheol Kim; Sun Yeou Kim
- Book ID
- 117474094
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 183 KB
- Volume
- 349
- Category
- Article
- ISSN
- 0304-3940
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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe