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Excessive dopamine neuron loss in progressive supranuclear palsy

โœ Scribed by Karen E. Murphy; Tanya Karaconji; Craig D. Hardman; Glenda M. Halliday

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
97 KB
Volume
23
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Abstract

Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy. ยฉ 2007 Movement Disorder Society

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