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Excess Risk for Contralateral Breast Cancer in CHEK2*1100delC Germline Mutation Carriers

✍ Scribed by Annegien Broeks; Lot de Witte; Anke Nooijen; Angelina Huseinovic; Jan G.M. Klijn; Flora E. van Leeuwen; Nicola S. Russell; Laura J. van't Veer

Book ID
111574980
Publisher
Springer US
Year
2004
Tongue
English
Weight
48 KB
Volume
83
Category
Article
ISSN
0167-6806

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## Abstract Genetic risk factors for male breast cancer (MBC) are poorly understood. High penetrance genes such as BRCA1 or BRCA2 account for only a small proportion of the disease. A 1100delC mutation in CHEK2 (previously known as CHK2), a cell‐cycle checkpoint kinase, has been implicated in predi