The -4 allele of apolipoprotein E (APOE) is associated with increased risk of Alzheimer's disease (AD), but the pathogenic mechanism is unknown. The 5-repeat allele of a CGG repeat polymorphism in the 5 untranslated region of the very low-density lipoprotein receptor (VLDL-R) gene, a receptor for ap
Exceptional Parental Longevity Associated with Lower Risk of Alzheimer's Disease and Memory Decline
β Scribed by Richard B. Lipton; Jamie Hirsch; Mindy J. Katz; Cuiling Wang; Amy E. Sanders; Joe Verghese; Nir Barzilai; Carol A. Derby
- Book ID
- 109132163
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 151 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0002-8614
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It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE"2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE\*2 allele in the pathogenesis of EOAD in a Dutch population-b
## Abstract Alzheimer's disease (AD) is the most common form of dementia and is pathologically characterized by senile plaques, neurofibrillary tangles, synaptic disruption and loss, and progressive neuronal deficits. The exact mechanism(s) of AD pathogenesis largely remain unknown. With advances i