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Excavating an Active Site: The Nucleobase Specificity of Ribonuclease A †

✍ Scribed by Kelemen, Bradley R.; Schultz, L. Wayne; Sweeney, Rozamond Y.; Raines, Ronald T.


Book ID
126787844
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
280 KB
Volume
39
Category
Article
ISSN
0006-2960

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✍ Dinshaw J. Patel; Lita L. Canuel; Frank A. Bovey 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 493 KB 👁 1 views

## Abstract The C~2~H resonance of the active site histidine residue designated AS‐2, which has the lower p__K__~__a__~ of the two active site histidines, has been correlated in both RNase A and RNase S by comparing the pH 3 to 5.5 regions of the chemical shift titration curves, the effect of the i