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Examination of the effect of age and acquired immunity on the susceptibility of mice to infection with Aspergillus fumigatus

✍ Scribed by M. J. Corbel; Susan M. Eades

Publisher
Springer Netherlands
Year
1977
Tongue
English
Weight
565 KB
Volume
60
Category
Article
ISSN
0301-486X

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✦ Synopsis

Adult CBA mice showed considerably greater resistance to experimental infection with Aspergillus fumigatus than young animals of the same strain (P less than 0.01). Furthermore, in contrast with the young mice, the susceptibility of the adults was only moderately increased by treatment with cortico-steroids. On the other hand, immunosuppressive treatments producing severe depression of lymphocyte function greatly increased susceptibility to lethal infection and promoted fungal growth in a wide range of tissues. These observations suggested a role for specific acquired immunity in the relatively high resistance to experimental aspergillosis shown by older mice.

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## Abstract Invasive aspergillosis caused by the mould __Aspergillus fumigatus__ is a life‐threatening lung or systemic infection in the immunocompromised host. In this study, a protective immune response against the disease was achieved in two infected rabbits, and the cellular fungal antigenic pr