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Examination of Novel Zinc-Binding Groups for Use in Matrix Metalloproteinase Inhibitors

โœ Scribed by Puerta, David T.; Cohen, Seth M.


Book ID
127286972
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
262 KB
Volume
42
Category
Article
ISSN
0020-1669

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A novel model to assess the in vivo bioactivity of matrix metalloproteinase (MMP) inhibitors is described. A solution containing the target enzyme, either stromelysin (MMP-3) or collagenase (MMP-1), was put inside dialysis tubing which was then implanted either intraperitoneally or subcutaneously in