Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6)
β Scribed by B. C. McKinney; C. Y. Chow; M. H. Meisler; G. G. Murphy
- Book ID
- 111273204
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 424 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1601-1848
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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi
## Abstract In myelinated axons, voltageβgated sodium channels specifically cluster at the nodes of Ranvier, while voltageβgated potassium channels are located at the juxtaparanodes. These characteristic localizations are influenced by myelination. During development, Nav1.2 first appears in the pr