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Exacerbation of migraine with paroxetine: Case report

✍ Scribed by Alan Currie; Ann Ryman; R. Hamish McAllister-Williams

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
146 KB
Volume
10
Category
Article
ISSN
0885-6222

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✦ Synopsis

Abstract

There has been one case reported in the literature (Medline search December 1994) of a serotonin selective re‐uptake inhibitor (SSRI), fluoxetine, being associated with the development of classic migrainous symptoms (Larson, 1993). We now report a case of severe exacerbation of migraine with another SSRI, paroxetine.

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Paroxetine is a new antidepressant, a selective serotonin reuptake inhibitor (SSRI), which has marked inhibiting effect on microsomal cytochrome P450 enzymes in human liver. In this case report we describe two patients whose serum trimipramine and desmethyltrimipramine concentrations increased marke