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Exacerbation of acetaminophen hepatotoxicity by thalidomide and protection by nicotinic acid amide

✍ Scribed by Hans Kröger; Monika Klewer; Regina Grätz; Annette Dietrich; Heinrich Ockenfels; Ralf Miesel

Book ID
113328722
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
478 KB
Volume
26
Category
Article
ISSN
0306-3623

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## Abstract Mice pretreated with the peroxisome proliferator clofibrate (CFB) are highly resistant to acetaminophen (APAP)‐induced hepatotoxicity. The objective of the present study was to investigate whether the increase in hepatic catalase activity following CFB pretreatment plays a role in this