Ex vivo tissue-type independence in proton-resonance frequency shift MR thermometry

✍ Scribed by Rober T. D. Peters; R. Scott Hinks; R. Mark Henkelman

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 741 KB
• Volume: 40
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910400316

✦ Synopsis

The temperature sensitivity of the proton-resonance frequency (PRF) has proven valuable for the monitoring of MR image-guided thermal coagulation therapy. However, there is significant inconsistency in reported values of the PRF-thermal coefficient, as measured from experiments encompassing a range of in vivo and ex vivo tissue types and experimental conditions. A method of calibrating the temperature dependence of the PRF is described and results are presented that indicate a tissue-type independence. To this end, other possible mechanisms for variations in the PRF-thermal coefficient are suggested, including physiological perturbations and volume magnetic susceptibility effects from geometry and orientation.