𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ex vivo and in vivo Evaluation of [18F]PR04.MZ in Rodents: A Selective Dopamine Transporter Imaging Agent

✍ Scribed by Patrick J. Riss; Fabian Debus; René Hummerich; Ulrich Schmidt; Patrick Schloss; Hartmut Lueddens; Frank Roesch

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
449 KB
Volume
4
Category
Article
ISSN
1860-7179

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Exercise elevates dopamine D2 receptor i
Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: In vivo imaging with [18F]fallypride
✍ Marta G. Vučcković; Quanzheng Li; Beth Fisher; Angelo Nacca; Richard M. Leahy; J 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 291 KB

## Abstract The purpose of the current study was to examine changes in dopamine D2 receptor (DA‐D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and __in vivo__ positron emission tomography (P

Synthesis, quality control and in vivo e
Synthesis, quality control and in vivo evaluation of [123I] rhTIMP-2, a potential tumour-imaging agent
✍ Ruth Oltenfreiter; Ingrid Burvenich; Ludovicus Staelens; Annabelle Lejeune; Fran 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 151 KB 👁 1 views

Matrix metalloproteinases (MMPs) are enzymes involved in the turnover of the extracellular matrix. Their overexpression in tumours may provide a target for diagnostic imaging by using labelled MMP inhibitors. MMPs are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). The enhan

Synthesis, radiosynthesis and in vivo ev
Synthesis, radiosynthesis and in vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter
✍ S. De Bruyne; T. L. Boos; L. wyffels; J. L. Goeman; K. C. Rice; F. De Vos 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 223 KB 👁 1 views

## Abstract Dopamine transporter (DAT) neuroimaging is a useful tool in Parkinson's disease diagnosis, staging and follow‐up providing information on the integrity of the dopaminergic neurotransmitter system __in vivo__. 4‐(2‐(Bis(4‐fluorophenyl)methoxy)ethyl)‐1‐(4‐iodobenzyl)piperidine (7) has nan

In vitro and in vivo evaluation of the b
In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist 11C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate
✍ Jogeshwar Mukherjee; Tanjore K. Narayanan; Bradley T. Christian; Bingzhi Shi; Ke 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 3 views

The in vitro autoradiographic binding characteristics as well as in vivo imaging characteristics of a dopamine D2 receptor agonist, (R,S)-2-(N-propyl-N-1Ј-11 Cpropyl)amino-5-hydroxytetralin ( 11 C-5-OH-DPAT), were studied. In 3 H-spiperone assays using rat striata, 5-OH-DPAT exhibited an affinity of

6-[123I]Iodo-2-[[4-(2-methoxyphenyl) pip
6-[123I]Iodo-2-[[4-(2-methoxyphenyl) piperazin-1-yl]methyl]imidazo[1,2-a]pyridine as potential SPECT agent for imaging dopamine D4 receptor: synthesis and in vivo evaluation in a nonhuman primate
✍ David Alagille; Andrei O. Koren; Greg Kudej; Julie Staley; Kelly Cosgrove; John 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 129 KB 👁 1 views

## Abstract The dopamine D~4~ receptor subtype has drawn considerable attention due to its potential implication in schizophrenia and erectile dysfunction. 6‐[^123^I]Iodo‐2‐[[4‐(2‐methoxyphenyl)piperazin‐1‐yl]methyl]imidazo[1,2‐__a__]pyridine [^123^I]‐1, a potent and selective new dopamine D~4~ ago