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Ex vivo activated memory t-lymphocytes as adoptive cellular therapy of human soft-tissue sarcoma targets with potentiation by Cis-diamminedichloroplatinum (II)

✍ Scribed by Jay E. Gold; Ted R. Masters; Norman D. Bloom; Michail K. Shafir; Michael J. Klein; Samuel Kenan; Michael E. Osband

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 959 KB
Volume: 58
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930580403

No coin nor oath required. For personal study only.

✦ Synopsis

specificity in one patient. Restriction of ALT-cell lysis and IFN-y release against HLA-A2+ autologous and one allogeneic HLA-A2+ STS tumor target, but not other non-STS targets, was demonstrated in another patient. These data suggest that CDDP may help render STS susceptible to tumorspecific, immune-mediated attack and that the combination of ALT and CDDP may lead to effective tumor-specific chemoimmunotherapy in patients with metastatic STS. 0

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✍ Dr. Jay E. Gold; Ira J. Bleiweiss; Alisan B. Goldfarb; Joel J. Bauer; Irwin M. G 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 677 KB

Autolymphocyte therapy (ALT) is adoptive cellular therapy of cancer using ex vivo activation of autologous peripheral blood lymphocytes (PBL). Memory T cells are the principal effector population in ALT, with in vivo activity in patients with metastatic renal cell carcinoma (RCC) and melanoma, and e