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Evolving strategies for global gene expression analysis of cancer

✍ Scribed by Bradley P. Coe; Raj Chari; William W. Lockwood; Wan L. Lam

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 206 KB
Volume: 217
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21554

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The advent of high throughput gene expression profiling, from microarrays to sequence based assays has yielded vast insight into the biology of tumors. New technologies are constantly being unveiled which promise to generate more accurate maps of tumor gene deregulation, and demand the development of new strategies in data analysis. This review details the challenges faced in profiling tumor transcriptomes, and highlights the emerging strategies to utilize global profiling approaches to advance our understanding of causal genetic and epigenetic events and their impact on gene expression and tumor phenotype and behavior, through high throughput profiling, and integration of multiple dimensions of genomic data. J. Cell. Physiol. 217: 590–597, 2008. © 2008 Wiley‐Liss, Inc.

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