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✦   LIBER   ✦

Evolving Role of Radiation Therapy for Hematologic Malignancies

✍ Scribed by Chung K. Lee

Book ID
118012869
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
650 KB
Volume
20
Category
Article
ISSN
0889-8588

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✦ Synopsis

Radiation therapy continues to play a paramount role in the therapy of hematologic malignancies, whether as definitive therapy, as consolidation after chemotherapy, as part of bone marrow transplantation protocols, or in palliation. During the past 2 decades, significant advances in radiation therapy have occurred, including the evolution of involved-field irradiation and the adoption of conformal radiation administration. It is hoped that modern techniques will reduce the long-term sequelae associated with radiation-based treatments.

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## Abstract The double‐stranded RNA‐dependent kinase PKR has been described for many years as strictly a pro‐apoptotic kinase. Recent data suggest that the main purpose of this kinase is damage control and repair following stress and, if all else fails, apoptosis. Aberrant activation of PKR has bee