Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics

✍ Scribed by Christian Julián Villabona-Arenas; Paolo Marinho de Andrade Zanotto

• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 615 KB
• Volume: 11
• Category: Article
• ISSN: 1567-1348
• DOI: 10.1016/j.meegid.2011.02.007

✦ Synopsis

Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype.