Evolutionary Conservation of Protein Backbone Flexibility
✍ Scribed by Sandra Maguid; Sebastián Fernández-Alberti; Gustavo Parisi; Julián Echave
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 222 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-2844
No coin nor oath required. For personal study only.
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## Abstract Protein structure prediction and design often involve discrete modeling of side‐chain conformations on structural templates. Introducing backbone flexibility into such models has proven important in many different applications. Backbone flexibility improves model accuracy and provides a
## Background Determining the complete repertoire of protein structures for all soluble, globular proteins in a single organism has been one of the major goals of several structural genomics projects in recent years. ## Results We report that this goal has nearly been reached for several "minimal