Evolutionary Consequences of Selected Locus-specific Variations in Epistasis and Fitness Contribution in Kauffman'sNKModel
✍ Scribed by Daniel Solow; Apostolos Burnetas; Theresa Roeder; Neil S. Greenspan
- Book ID
- 102614034
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 211 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0022-5193
No coin nor oath required. For personal study only.
✦ Synopsis
Mathematical analysis and computer simulations are used to evaluate three modifications to Kauffman's NK model in an attempt to incorporate unexplored aspects of epistatic interaction between loci in genome evolution. Two modifications-one to the amount and the other to the distribution of epistatic interaction-further support Kauffman's conclusion that high levels of epistatic interaction lead to a decrease in overall fitness of the genome. The third model, however, provides a condition under which increased epistatic interaction at certain loci results in higher genome fitness.