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Evolutionary and clinical neocentromeres: two faces of the same coin?

โœ Scribed by Oronzo Capozzi; Stefania Purgato; Ludovica Verdun di Cantogno; Enrico Grosso; Roberto Ciccone; Orsetta Zuffardi; Giuliano Della Valle; Mariano Rocchi


Publisher
Springer
Year
2008
Tongue
English
Weight
294 KB
Volume
117
Category
Article
ISSN
0009-5915

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## Abstract Dysregulation of genes that control cellโ€cycle progression and DNA repair is a hallmark of tumorigenesis. It is becoming increasingly apparent, however, that these defects also contribute to degeneration of postโ€mitotic neurons under certain conditions. The gene for ataxiaโ€telangiectasi