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Evolutional and clinical implications of the epigenetic regulation of protein glycosylation

✍ Scribed by Tomislav Horvat; Vlatka Zoldoš; Gordan Lauc

Book ID
107687382
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
238 KB
Volume
2
Category
Article
ISSN
1868-7075

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Chronic alcohol exposure leads to the appearance of carbohydrate-deficient transferrin (CDT), a N-glycosylated protein and sialic acid-deficient apolipoprotein E (apoE), an O -glycosylated protein. We show that chronic ethanol treatment destabilizes sialyltransferase (ST) mRNA resulting in a concomi