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Evolution of the Phenomenon of Drug-Resistance. II. Studies of the Extracellular and Intracellular Derivatives of Folic Acid in Relation to Resistance to Sulphathiazole and Growth Factor Requirements

✍ Scribed by Sevag, M. G.; Yokota, T.

Book ID: 120131557
Publisher: The Royal Society
Year: 1960
Tongue: English
Weight: 634 KB
Volume: 153
Category: Article
ISSN: 0080-4649
DOI: 10.1098/rspb.1960.0097

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## Abstract Prolonged hypoxia induced transient drug resistance in Chinese hamster lung fibroblasts. Previously hypoxic cells were resistant to adriamycin and resistant to etoposide. Complete recovery of etoposide sensitivity was observed following re‐aeration for 24 hr. A change in P‐glycoprotein